Metrum Institute Training Courses

New for 2008-2009! As part of the Open Educational Resource (OER) movement promoted by a growing number of educational institutions and organizations, Metrum Institute will make its course content available online. Two licensing options will be made available: Open Courseware and Complete Courseware. What's the difference between these two options? Go here for more information.

Want to view all of our current courses at a glance? Click here for PDF version.

Course #	Course Title	Dates	Cost*	Outline	Courseware	Registration
MI101-W	Introduction to Pharmacokinetics and Pharmacodynamics MI101 provides a thorough introduction to fundamental concepts in pharmacokinetics and pharmacodynamics through lectures and problem-solving lab sessions that emphasize physiologic concepts and real-world applications. Content is consistent with expectations for an introductory PK course in a professional pharmacy curriculum. Prerequisites: none	Spring 2009-- TBD	$3,000*		Coming soon	Register now
MI110-W	NMQual for NONMEM® Software Installation & Qualification MI110 demonstrates basic NMQual techniques on a Windows platform, with the aim of executing rapid, well characterized NONMEM® installations. Prerequisites: none	Tuesday, Oct. 21, 2008 1-3PM EST Other dates available--see course outline	$200*		Coming soon	Register now
MI120-W	Brief Introduction to R and MItools MI120 is a brief, but intensive hands-on introduction to the R language, with specific focus on functions and features useful in pharmacometrics. This course also includes an introduction to the MItools package, which is used in later courses for processing of NONMEM® runs. Prerequisites: none	Spring 2009: Feb. 3 & 6	$300*		Coming soon	Register now
MI125-W	Introduction to R Programming MI125 provides a comprehensive introduction to the R statistical programming language through lecture and hands-on lab sessions. Topics covered include data import/export, writing scripts and functions, manipulating data objects, graphics, and basic statistical methods.	TBD	$1500		Coming soon	Closed
MI210-W	Essentials of Population PKPD Modeling & Simulation MI210 provides an extensive overview of essential topics in population pharmacokinetics and pharmacodynamics, including: nonlinear-mixed effects modeling theory and implementation, data formatting requirements, population model development, model evaluation techniques, continuous PK-PD models, Monte Carlo simulation, and best practices. Instruction combines didactic lectures with hands-on exercises using R and the NONMEM® software. Prerequisites: Basic understanding of pharmacokinetic and pharmacodynamic principles, compartmental pharmacokinetic models, introductory statistics, familiarity with the R or S language. Applicable MI Courses include: MI120, MI101, MI201, or contact instructor.	Sept. 9 - Dec. 12, 2008	$3000*		Open Courseware Complete Courseware	Register now**
MI212-W	Advanced Topics in Population PK-PD Modeling & Simulation MI212 extends the material inititated in MI210 including a detailed overview of advanced topics in population pharmacokinetics and pharmacodynamics: inter-occasion variability, mixture models, truncated continuous data (BQL), nonlinear-pharmacokinetic models, models for parent & metabolite plasma and urine data, indirect-response pharmacodynamic models, models for tolerance, precursor pools and complex systems, disease progression models, population PK study design, and clinical trial simulation. Instruction combines didactic lectures with hands-on exercises using R and the NONMEM® software. Prerequisites: MI210 and related prerequisites.	Feb. 10 - May 1, 2009	$3000*		Coming soon	Register now
MI220-W	Intermediate R Programming for Pharmacometrics MI220 covers intermediate-level R programming topics with a focus on pharmacometric applications through lecture and hands-on lab sessions. This course also makes extensive use of the MItools package to teach and implement tasks such as population PK data set assembly and manipulation, post-processing of modeling output, exploratory and report-quality graphics using traditional and lattice functions and summarizing bootstrap and predictive check model qualification methods.	TBD	$1500		Coming soon	Closed
MI250	Introduction to Bayesian PK-PD Modeling & Simulation MI250 is an intensive, 3-day onsite course that provides an introduction to Bayesian modeling and the practical use of WinBUGS and R for PK-PD applications. Prerequisites: Experience with PK-PD modeling and some familiarity with nonlinear regression, mixed effects modeling and R (or S-Plus) is requred. Applicable MI courses include: MI 210 and MI212.	TBD	$2475*		Coming soon	Closed
MI255	Exposure-Response Modeling of Categorical, Count and Time-to-Event Data Using Bayesian and Maximum Likelihood Methods MI255 provides and introduction to modeling of categorical, count, and time-to-event data, and the practical use of NONMEM® and WinBUGS for such applications. Prequisites: Experience with PK-PD modeling and some familiarity with nonlinear regression, mixed effects modeling and R (or S-Plus) is required. Prior experience with Bayesian modeling using WinBUGS is desirable but not required. The course includes a short introduction to Bayesian principles and WinBUGS. Applicable MI courses include: MI210, MI212 and MI250, or contact instructor.	TBD	$2475*		Coming soon	Closed

*Discounts are offered to academic, non-profit and government agencies. See course outlines for details.
**Attendees who register after the start of the first class are able to view the previous lectures in their web browsers. All lectures and labs are recorded.

NONMEM® is licensed and distributed by ICON Development Solutions.