Metrum Institute Training Courses

New for 2008-2009! As part of the Open Educational Resource (OER) movement promoted by a growing number of educational institutions and organizations, Metrum Institute will make its course content available online. Two licensing options will be made available: Open Courseware and Complete Courseware. What's the difference between these two options? Go here for more information.

Want more details about our current courses? Click here for PDF course listing.

Upcoming Courses
Course #	Course Title	Dates	Cost*	Outline	Courseware	Registration
MI110-W	NMQual for NONMEM® Software Installation & Qualification MI110 demonstrates basic NMQual techniques on a Windows platform, with the aim of executing rapid, well characterized NONMEM® installations. Prerequisites: none	Multiple 2009 offerings: March 11, June 25, Sep 14, and Dec 9 1–3pm	$200*		Coming soon	Register now
MI220-W	R Programming for Pharmacometrics MI220 covers introductory through intermediate-level R programming topics with a focus on pharmacometric applications through lectures and hands-on lab sessions. Topics include basic R language constructs, data import/export, writing scripts and functions, manipulating data objects, traditional and lattice graphics, and basic statistical methods. This course also makes extensive use of the MIfuns package to teach and implement tasks such as population PK data set assembly, post-processing of Maximum Likelihood and Bayesian modeling output, exploratory and report-quality graphics and tables, and automation of compute intensive methods, such as bootstrapping and posterior predictive check model qualification. Students will be given access to a Metrum Institute web-application server for hands-on examples.	Feb.18-May 22, 2009. Wed and Fri 12-1pm	$2000*		Coming soon	Register now
Future Courses
MI101-W	Introduction to Pharmacokinetics and Pharmacodynamics MI101 provides a thorough introduction to fundamental concepts in pharmacokinetics and pharmacodynamics through lectures and problem-solving lab sessions emphasizing physiologic concepts and real-world applications. Content in this course is consistent with expectations for an introductory pharmacokinetics course in a professional Pharmacy curriculum. Prerequisites: none	Sept.-Dec., 2009 - exact dates TBD (12 weeks plus 2 make-up weeks) Mon 7–9pm, Wed 7–8pm	$3,000*		Coming soon	Not yet open
MI120-W	Brief Introduction to R and MIfuns MI120 is a brief but intensive hands-on introduction to the R language, with specific focus on functions and features useful in pharmacometrics. This course also includes an introduction to the MIfuns package, which is used in later courses for processing of NONMEM® runs and other modeling/simulation tasks. Students will be given access to a Metrum Institute web-application server for hands-on examples.	Multiple Offerings: March and Sep 2009, exact dates TBD (1 week each) Tue 2–4pm, Fri 2–4pm	$300*		Coming soon	Not yet open
MI210-W	Essentials of Population PKPD Modeling & Simulation MI210 provides an extensive overview of topics in population pharmacokinetics and pharmacodynamics, including nonlinear-mixed effects modeling theory and implementation, data formatting requirements, population model development, model evaluation techniques, continuous PK-PD models, Monte Carlo simulation, and best practices. Instruction combines didactic lectures with hands-on exercises using R, MIfuns, and the NONMEM® software. Students will be given access to a Metrum Institute web-application server for hands-on examples. Prerequisites: Basic understanding of pharmacokinetic and pharmacodynamic principles, compartmental pharmacokinetic models, introductory statistics, familiarity with the R or S language. Applicable MI Courses include: MI120, MI101, MI201, or contact instructor.	Sept. - Dec., 2010 - exact dates TBD (12 weeks plus 2 make-up weeks) Tue 2–4pm, Fri 2–3pm	$3000*		Open Courseware Complete Courseware	Closed
MI212-W	Advanced Topics in Population PK-PD Modeling & Simulation MI212 builds upon the material covered in MI210. It provides a detailed overview of advanced topics in population pharmacokinetics and pharmacodynamics: inter-occasion variability, mixture models, truncated continuous data (BQL), nonlinear-pharmacokinetic models, models for parent and metabolite plasma and urine data, indirect-response pharmacodynamic models, models for tolerance, precursor pools, cell lifespan, and other semi-mechanistic systems, disease progression models, population PK study design, and clinical trial simulation. Instruction combines didactic lectures with hands-on exercises using R, MIfuns, and the NONMEM® software. Students will be given access to a Metrum Institute web-application server for hands-on examples. Prerequisites: MI210 and related prerequisites.	Sept.- Dec., 2009 – exact dates TBD (12 weeks plus 2 make-up weeks) Tue 2–4pm, Fri 2–3pm	$3000*		Coming soon	Register now
MI250	Introduction to Bayesian PK-PD Modeling & Simulation MI250 is an intensive, hands-on, 3-day course that provides an introduction to Bayesian modeling theory and the practical use of WinBUGS and R for PK-PD applications. In addition to basic concepts, this new course includes instruction on the BUGS PK-PD model library, an open-source tool developed by Metrum Institute. This library facilitates the implementation of population PK-PD models in WinBUGS for compartmental models described by algebraic, general linear and differential equations. Hands-on software requirements include WinBUGS and R (both freely available). Students will provide their own laptop computers. Prerequisites: Experience with PK-PD modeling and some familiarity with nonlinear regression, mixed effects modeling and R (or S-Plus) is requred. Applicable MI courses include: MI 210 and MI212.	June 3-5, 2009 Wed–Fri 8:30am–4:30pm	$3000*		Coming soon	Not yet open
MI255	Exposure-Response Modeling of Categorical, Count and Time-to-Event Data Using Bayesian and Maximum Likelihood Methods MI255 is an intensive, hands-on, 3-day course providing an introduction to modeling of categorical, count, and time-to-event data, and the practical use of WinBUGS and NONMEM® for such applications. The course provides some basic theory and illustrates some of the advantages of using Bayesian methods for these types of data sets. Hands-on software requirements include WinBUGS and R (both freely available). Students will provide their own laptop computers. Prequisites: Experience with PK-PD modeling and some familiarity with nonlinear regression, mixed effects modeling and R (or S-Plus) is required. Prior experience with Bayesian modeling using WinBUGS is desirable but not required. The course includes a short introduction to Bayesian principles and WinBUGS. Applicable MI courses include: MI210, MI212 and MI250, or contact instructor.	July 13-15, 2009 Mon–Wed 8:30am–4:30pm	$3000*		Coming soon	Not yet open

*Discounts are offered to academic, non-profit and government agencies. See course outlines for details.
**Attendees who register after the start of the first class are able to view the previous lectures in their web browsers. All lectures and labs are recorded.

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